Tissue-specific Tropomyosin Isoform Composition
نویسندگان
چکیده
منابع مشابه
Tropomyosin isoform diversity and neuronal morphogenesis.
Tropomyosins (Tm) are a large family of isoforms obtained from multiple genes and by extensive alternative splicing. They bind in the alpha-helical groove of the actin filament and are therefore core components of this extensive cytoskeletal system. In non-muscle cells the Tm isoforms have been implicated in a diversity of processes including cytokinesis, vesicle transport, motility, morphogene...
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The actin cytoskeleton is the primary polymer system within cells responsible for regulating cellular stiffness. While various actin binding proteins regulate the organization and dynamics of the actin cytoskeleton, the proteins responsible for regulating the mechanical properties of cells are still not fully understood. In the present study, we have addressed the significance of the actin asso...
متن کاملMolecular Cardiology Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform
Background—Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1␣ (also called ␣-TM) is the predominant TM isoform in human hearts, the precise TM isoform composition remains unclear. Methods and Results—In this study, we quantified for the first time the levels of striated muscle TM isoforms in human hear...
متن کاملMolecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
BACKGROUND Tropomyosin (TM), an essential actin-binding protein, is central to the control of calcium-regulated striated muscle contraction. Although TPM1alpha (also called alpha-TM) is the predominant TM isoform in human hearts, the precise TM isoform composition remains unclear. METHODS AND RESULTS In this study, we quantified for the first time the levels of striated muscle TM isoforms in ...
متن کاملTropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells
An antibody against purified chicken skeletal muscle tropomyosin is used in indirect immunofluorescence to visualize the localization of tropomyosin in a variety of nonmuscle cells. The antibody produces a fluorescent pattern which is very similar to that obtained with an actin-specific antibody. This pattern is composed of fluorescent fibers which are shown to be coincident with the fibers see...
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ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 2005
ISSN: 0022-1554,1551-5044
DOI: 10.1369/jhc.4a6505.2005